Computation on Percentage Ionization
Directions: Calculate the percent ionizatio
Computation on Percentage Ionization
Directions: Calculate the percent ionization of amobarbital at pH 2.0, 5.5, and 8.0 and determine at what pH the drug is readily excreted. Show all the necessary solutions. (5 points each)
2. Short Essay on Acid-Base Case
Directions: Analyze the case given below and evaluate what drug is recommended for this patient.
Case: A long-distance truck driver comes into the pharmacy complaining of seasonal allergies. He asks you to recommend an agent that will act as an antihistamine but that will not cause drowsiness. He regularly takes TUMS for indigestion due to the bad food that he eats while on the road.
3. Identify the functional groups present in Zyrtec and Tavist, and evaluate the effect of each functional group on the ability of the drug to cross-lipophilic membranes (e.g., blood–brain barrier). Based on your assessment of each agent’s ability to cross the blood–brain barrier (and, therefore, potentially cause drowsiness), provide a rationale for whether the truck driver should be taking Zyrtec or Tavist.