Please answer these questions 4. What are the key lifestyle modifications recomm

Please answer these questions
4. What are the key lifestyle modifications recomm

Please answer these questions
4. What are the key lifestyle modifications recommended for heart failure management?
5. What are the Class I drugs recommended for heart failure with reduced ejection fraction (HFrEF) according to ESC 2021 guidelines?
6. What are the benefits of ACE inhibitors in the treatment of HFrEF?
7. What are the common side effects of ACE inhibitors?
8. Can you provide examples of ACE inhibitors?
1. What is neprilysin, and how does its inhibition contribute to the treatment of heart failure?
2. How do ARNIs (Valsartan-sacubitril) impact the renin-angiotensin-aldosterone system (RAAS)?
3. Why should valsartan-sacubitril not be administered concurrently or within 36 hours of an ACE inhibitor, and what is the associated risk?

Visit the site: https://www.drugabuse.gov/drug-topics/trends-statistics and choo

Visit the site: https://www.drugabuse.gov/drug-topics/trends-statistics and choo

Visit the site: https://www.drugabuse.gov/drug-topics/trends-statistics and choose one of the articles or surveys linked on the page then address the following in your discussion.
Provide an overview of the resource you read from the National Institute on Drug Abuse Trends & Statistics
Describe how the information in the resource you chose relates to the information in Chapter 1 of the text regarding problems caused by drug use in society.
Based on the reading in Chapter 2 on reasons individuals may use drugs, discuss some reasons for the trends you reported. Be sure to tie in the information from the text on reasons for use in this discussion.
Reading:
https://purdueuniversityglobal.vitalsource.com/reader/books/9780357191439/epubcfi/6/2[%3Bvnd.vst.idref%3DM1]!/4/2/4/2%4050:0

In a 2-3-page descriiptive essay: Explain properties of drugs including the fol

In a 2-3-page descriiptive essay:
Explain properties of drugs including the fol

In a 2-3-page descriiptive essay:
Explain properties of drugs including the following:
Bioavailability
Effective dose
Site of action
Process of neurotransmission.
Based on these properties, discuss at least three ways drugs affect the human body.
Explain drug-taking behavior as discussed in the supplemental reading article (see below) and in Chapter 20 of the text.
Using the scenario found below, discuss three drug-taking behaviors.
The paper should include reference to the textbook and the supplemental reading article.
Article: Hayley, A. C., Hart, C. L., O’Malley, K. Y., Stough, C. K. K., & Downey, L. A. (2019). Risky driving behaviours among stimulant drug users and the role of aggression: Findings from a national survey. Addiction, 114(12), 2187–2196. https://doi.org/10.1111/add.14759
Permalink: https://libauth.purdueglobal.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=139764995&site=eds-live
Scenario:
Darren is a 28-year-old Caucasian father of two children. He lives with his girlfriend who also has two children. He has smoked cannabis consistently since his teens. His step-father also used cannabis daily. He has also used pain medication frequently for a problem with his back caused by a car accident in his late teens. This medication is often prescribed, but he has also used “extra” medication from family and friends. He does not view this is misuse since it is for a legitimate medical condition. Following the accident, he found it difficult to catch up in school, and did not finish high school. He states that he plans to complete his G.E.D. Darren has struggled to maintain consistent work, throughout his early adulthood. He has recently worked in the food industry and in construction. He has frequent disagreements with managers and bosses, often “flying off the handle” and has been described as an “angry person” by some acquaintances. This has accounted for some of his unstable work history, as he has lost jobs due to outbursts at work or disagreements with managers. In addition, he struggles to maintain steady work in construction due to the season nature of the trade. The last few summers he has worked with a roofing crew. He and some of his coworkers have begun using cocaine.
Your assignment should be a 2-3-page descriiptive essay, not including the title and reference pages, and should include the following elements:
Title page: Provide your name, title of assignment, course and section number, and date.
Body: Answer all the questions in complete sentences and paragraphs.
Your responses should reflect professional writing standards, using proper tone and language. The writing and writing style should be correct and accurate, and reflect knowledge of skills and practice in the human service profession.
Reference page: Sources listed in APA format.
Include a minimum of two scholarly or academic sources to support your responses and conclusions.
Use Arial or Times New Roman 12-point font, double-spaced and left aligned.
Use standard 1″ margins on all sides.
Use APA formatting and citation style.
textbook link :
https://purdueuniversityglobal.vitalsource.com/reader/books/9780357191439/epubcfi/6/2[%3Bvnd.vst.idref%3DM1]!/4/2/4/2%4050:0

Visit the site: https://www.drugabuse.gov/drug-topics/trends-statistics and choo

Visit the site: https://www.drugabuse.gov/drug-topics/trends-statistics and choo

Visit the site: https://www.drugabuse.gov/drug-topics/trends-statistics and choose one of the articles or surveys linked on the page then address the following in your discussion.
Provide an overview of the resource you read from the National Institute on Drug Abuse Trends & Statistics
Describe how the information in the resource you chose relates to the information in Chapter 1 of the text regarding problems caused by drug use in society.
Based on the reading in Chapter 2 on reasons individuals may use drugs, discuss some reasons for the trends you reported. Be sure to tie in the information from the text on reasons for use in this discussion.
Reading:
https://purdueuniversityglobal.vitalsource.com/reader/books/9780357191439/epubcfi/6/2[%3Bvnd.vst.idref%3DM1]!/4/2/4/2%4050:0

In a 2-3-page descriiptive essay: Explain properties of drugs including the fol

In a 2-3-page descriiptive essay:
Explain properties of drugs including the fol

In a 2-3-page descriiptive essay:
Explain properties of drugs including the following:
Bioavailability
Effective dose
Site of action
Process of neurotransmission.
Based on these properties, discuss at least three ways drugs affect the human body.
Explain drug-taking behavior as discussed in the supplemental reading article (see below) and in Chapter 20 of the text.
Using the scenario found below, discuss three drug-taking behaviors.
The paper should include reference to the textbook and the supplemental reading article.
Article: Hayley, A. C., Hart, C. L., O’Malley, K. Y., Stough, C. K. K., & Downey, L. A. (2019). Risky driving behaviours among stimulant drug users and the role of aggression: Findings from a national survey. Addiction, 114(12), 2187–2196. https://doi.org/10.1111/add.14759
Permalink: https://libauth.purdueglobal.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=139764995&site=eds-live
Scenario:
Darren is a 28-year-old Caucasian father of two children. He lives with his girlfriend who also has two children. He has smoked cannabis consistently since his teens. His step-father also used cannabis daily. He has also used pain medication frequently for a problem with his back caused by a car accident in his late teens. This medication is often prescribed, but he has also used “extra” medication from family and friends. He does not view this is misuse since it is for a legitimate medical condition. Following the accident, he found it difficult to catch up in school, and did not finish high school. He states that he plans to complete his G.E.D. Darren has struggled to maintain consistent work, throughout his early adulthood. He has recently worked in the food industry and in construction. He has frequent disagreements with managers and bosses, often “flying off the handle” and has been described as an “angry person” by some acquaintances. This has accounted for some of his unstable work history, as he has lost jobs due to outbursts at work or disagreements with managers. In addition, he struggles to maintain steady work in construction due to the season nature of the trade. The last few summers he has worked with a roofing crew. He and some of his coworkers have begun using cocaine.
Your assignment should be a 2-3-page descriiptive essay, not including the title and reference pages, and should include the following elements:
Title page: Provide your name, title of assignment, course and section number, and date.
Body: Answer all the questions in complete sentences and paragraphs.
Your responses should reflect professional writing standards, using proper tone and language. The writing and writing style should be correct and accurate, and reflect knowledge of skills and practice in the human service profession.
Reference page: Sources listed in APA format.
Include a minimum of two scholarly or academic sources to support your responses and conclusions.
Use Arial or Times New Roman 12-point font, double-spaced and left aligned.
Use standard 1″ margins on all sides.
Use APA formatting and citation style.
textbook link :
https://purdueuniversityglobal.vitalsource.com/reader/books/9780357191439/epubcfi/6/2[%3Bvnd.vst.idref%3DM1]!/4/2/4/2%4050:0

Please read all instructions very carefully. There are 4 scenarios and you will

Please read all instructions very carefully. There are 4 scenarios and you will

Please read all instructions very carefully. There are 4 scenarios and you will need to reference each scenario with 3 references that are within past 5 years. For each scenario you will need to write a written medication order that includes all 5 aspects required for a valid order. The order should be complete, accurate, and appropriate. Medication selected must be appropriate and considers all of the unique patient characteristics. Rationale for selection must be clear, complete, and appropriate. Please use the template that I have uploaded it has the scenarios in it. I have provided the rubrics/instructions, template that needs to be used. Please, reach out if you have any questions. please, do a good job in the case study. Thank you

1. Identify a health professions role needed in the care of the patient in this

1. Identify a health professions role needed in the care of the patient in this

1. Identify a health professions role needed in the care of the patient in this case. Explain your rationale for why the role you selected is needed. Reply to an existing post: In your reply to someone else’s post, discuss how the role that was posted is also needed by family members of the patient and needed by the other health care providers on the team.
Case Scenario Involving a Patient with Diabetes:
You have just been assigned to the new innovative clinic at LECOM. Three practices will be in one building! Medical students, pharmacy students, and dentistry students will collaborate together on an interprofessional team to improve patient outcomes. The following patient has been referred to your clinic for care. Included, you will find three documents:
A note from his prior physician who referred him to your clinic because of his complex medical needs and history of non-compliance.
A note from the last time he went to a dentist
His recent medication fill history from the pharmacy
Physician note: 9/15/15
HPI:
A 55 year old white male presented to the office complaining of being thirsty all the time and waking up at night to go to the bathroom. Patient has not been to an ophthalmologist in 5 years. Last year he did have a glucose reading over 200 mg/dL but denied having been diagnosed with diabetes. He is also a professional gambler and is upset because he frequently has to leave the table to urinate and reports occasional blurred vision. This is hurting him financially after he lost a huge hand in poker because he had to go so bad. PMH:
Hypertension
Hyperlipidemia
Medication History:
Atorvastatin PO 10 mg daily
Metoprolol succinate PO 25 mg daily
Fish Oil 1,200 mg PO once daily
Lisinopril 20 once daily
Social History:
1 pack per day smoker for 10 years
Drinks 1-2 Budweisers a day after work to relax
Family History:
Mother died of a heart attack 15 years ago
Father is living in an assisted living facility currently with DM2 and Hyperlipidemia
Brother is still alive and suffers from seizures
Physical Exam
Vital signs:
Height 6’0’’ Weight 220 lb BP 132/78 mm Hg Pulse 86 bpm RR 17 bpm Temp 97.4 F
Constitutional: Patient is A&O X3, well-nourished, well-developed and well-groomed
Head: The skull is normocephalic, atraumatic and without masses, patient’s facial expression is normal, no facial drooping, there is symmetry of the nasolabial folds
Eyes: Sclera is white and conjunctiva is pink, pupils are equally round and reactive to light
Ears: Otoscopic examination of external auditory canals and tympanic membranes is normal; there is a good cone of light.
Nose: Slight irritation of nasal mucosa with clear discharge
Mouth: Thin, milky white coating on buccal mucosa; lips are dry and pale pink; dentition indicates excess plaque and a purple discoloration of the gums.
Throat: Tongue is dry and midline with thin white coating
Neck: The neck is supple; trachea is midline; thyroid is not enlarged and no palpable nodules
Respiratory: The patient is relaxed and breathes without effort. Patient is not cyanotic and does not use accessory muscles for respiration. The chest expands symmetrically upon inspiration. There are no crackles, wheezes, rhonchi, stridor or pleural rubs.
Cardiovascular: Upon palpation of the chest, there are no heaves, lifts or thrills. The rate is normal, the rhythm is regular, S1 and S2 are normal, there are no murmurs, no gallops, and there are no rubs. Foot exam: Skin is dry and cracked at the heel; negative for signs of infection, laceration or ulceration; faint bilateral pulses present, SWM results: 6/10 left foot and 5/10 right foot
Labs: Taken Sep 20, 2015, fasting sample
2. Select and identify one person on the team in the video below who displayed the least able to work on a team. Why did you select this person? What specific actions, attitudes, or behaviors did the individual display that interfered with effective teamwork? Reply to an existing post: In your reply to someone else’s post, apply from the required reading in module 3, at least one principle of good interdisciplinary teamwork that could also improve his or her teamwork skills and justify your selection.
3.In analyzing this scenario, there were many steps in Sydney’s care where there was either a lack of communication or miscommunication. Which one do you feel was the most significant communication error impacting his care? Why? – Defend your selection. Apply one strategy from the content in this module that should be implemented to ensure that such events do not happen again.
Reply to an existing post: In your reply to someone else’s post, provide a second strategy that ensures that such events don’t happen again and describe your reasoning for your selection.
Case Scenario: A 32-year-old male, Sydney Worthington, was in a nursing home undergoing regular physical therapy. The nurse reported to his mother that Sydney almost fell twice during therapy last week, and was caught by the therapist. The nurse also reported that Sydney almost stumbled into her arms 3 days ago. His current medications include 200 mg phenytoin and 2000 mg levetiracetam, for control of seizures.
Past medical history includes a motorcycle accident nine years ago, that caused traumatic brain injury resulting in Sydney going into a coma. After Sydney came out of his coma, he was placed in the nursing home for long-term rehabilitation. He suffered a seizure at that time and was treated with phenytoin. He was then prescribed phenytoin orally, 100 mg once a day for maintenance. Six years later, when blood levels of phenytoin were tested, they were too low and the physician prescribed increased doses, up to 200 mg a day. This caused lethargy, and impaired balance and gait. His mother took Sydney to see a neurologist, who prescribed a different anti-seizure medication since phenytoin has adverse cardiovascular effects. The neurologist ordered the nursing home staff to administer levetiracetam 500 mg once a day along with phenytoin 200 mg/day, and slowly increase levetiracetam to 1000 mg a day. Once the patient was receiving 1000 mg/day of levetiracetam, the phenytoin was to be decreased to 100 mg/day. After levetiracetam was increased to 1000 mg twice a day, phenytoin was to be discontinued. These orders were faxed to the nursing home.
After 3 weeks, Sydney was being given 1000 mg/day levetiracetam, plus phenytoin 200 mg/day. When Sydney’s mother asked the nurses why the dose of phenytoin was not being decreased as the neurologist had recommended, the nurses indicated that the orders were not clear on how to decrease phenytoin. The mother contacted the neurologist’s office requesting that the order be redefined and sent to the nursing home, which was done immediately.
After 11 days, when his mother was informed by the nurse that Sydney lost his balance and nearly fell twice, she examined his medication chart and realized that for the past 11 days, Sydney was being given levetiracetam 1000 mg twice a day, in addition to phenytoin 200 mg/day, which was clearly not what the neurologist had ordered. The nursing staff had consulted with their on-site physician who never saw Sydney but had only looked at his chart.
4.Make an Original Post: Is this a breach of the patient’s confidentiality? Why? – Explain your rationale why this is or is not a breach.
Reply to an existing post: In your reply to someone else’s post, please explain how confidentiality (or lack thereof) in this scenario can affect a patient-provider relationship and potentially affect the health of the patient.
Case Scenario:
A student caring for actual patients (pharmacy student on a pharmacy practice experience/dental student working in a dental school-related clinic/medical student on a clinical rotation), posts negative comments about a patient/customer on his/her Facebook page with the privacy setting set to “friends.” Although the patient’s name was not posted, specific physical characteristics and medical, drug, and dental problems were included in the post.

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure t

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure t

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure to address the principle of the assay, how it is performed, and what information it can provide.
Pharmacodynamic assay: Radioligand assay (RIA) systems
Background information provided from the module: Radioligand assay (RIA) systems: utilizing a radioisotope such as 3H, 14C, 33P, or 35S incorporated into the compound of interest or the endogenous agonist, such assays can provide information about affinity and mode of action between the drug and the target (both receptors and enzymes). 3H remains the most popular and easiest to incorporate radioisotope in the common laboratory. Upon binding with the target, the radioactivity is measured and the unbound drug is removed. The leftover radioactivity now is directly related to the amount of bound drug to the target and thus is quantifiable if the amount of target and the originally applied radioactivity are known. This type of assay remains popular due to its relative ease and wide applicability. But it has limitations in that it requires extensive clean-up steps to remove non-specific binding of the radioactive labeled agent to plastic or cellular membranes as well as handling radioactive waste. To avoid generation of radioactive waste, newer techniques utilize scintillation proximity assay (SPA) beads that require binding of the radioisotope material in order to emit light and scintillate. The addition of such beads therefore quenches the radioactive material and binds it so that no filtration and removal of non-specific binding waste is necessary. One has to be aware though that the reduction in radioactivity is now indicative of the drug-target interaction since the fraction that binds with the target will not scintillate. More information on the underlying kinetics of radioligand assays: https://www.giffordbioscience.com/radioligand-binding-assay/ Pharmacokinetic in vitro assay: Parallel Artificial Membrane Permeability Assay (PAMPA).
Background information provided in the module: Parallel Artificial Membrane Permeability Assay (PAMPA): similar to IAM, PAMPA can only measure passive diffusion but more accurately correlates to jejunal intestinal permeability of compounds. In this assay, the drug is diluted in a buffer (donor solution) and topped with an immiscible barrier of a lipid layer on a filter plate usually consisting of a phospholipid such as phophatidyl choline in dodecane or egg lecithin. On top of the layer added is a pH-adjusted buffer (acceptor solution). The system is allowed to incubate for a set period of time and samples are collected from the original drug solution, the donor, and the acceptor solution after incubation and the concentration of the drug are measured. The advantage of this system is that the lipid layer is consistent and the compound is not forced through it as is the case in IAM. The thickness of the lipid layer, the pH of the buffer solution, and the composition of the lipid layer all contribute to the permeability rate and need to be carefully adjusted.

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure t

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure t

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure to address the principle of the assay, how it is performed, and what information it can provide.
Pharmacodynamic assay: Radioligand assay (RIA) systems
Background information provided from the module: Radioligand assay (RIA) systems: utilizing a radioisotope such as 3H, 14C, 33P, or 35S incorporated into the compound of interest or the endogenous agonist, such assays can provide information about affinity and mode of action between the drug and the target (both receptors and enzymes). 3H remains the most popular and easiest to incorporate radioisotope in the common laboratory. Upon binding with the target, the radioactivity is measured and the unbound drug is removed. The leftover radioactivity now is directly related to the amount of bound drug to the target and thus is quantifiable if the amount of target and the originally applied radioactivity are known. This type of assay remains popular due to its relative ease and wide applicability. But it has limitations in that it requires extensive clean-up steps to remove non-specific binding of the radioactive labeled agent to plastic or cellular membranes as well as handling radioactive waste. To avoid generation of radioactive waste, newer techniques utilize scintillation proximity assay (SPA) beads that require binding of the radioisotope material in order to emit light and scintillate. The addition of such beads therefore quenches the radioactive material and binds it so that no filtration and removal of non-specific binding waste is necessary. One has to be aware though that the reduction in radioactivity is now indicative of the drug-target interaction since the fraction that binds with the target will not scintillate. More information on the underlying kinetics of radioligand assays: https://www.giffordbioscience.com/radioligand-binding-assay/
Pharmacokinetic in vitro assay: Parallel Artificial Membrane Permeability Assay (PAMPA).
Background information provided in the module: Parallel Artificial Membrane Permeability Assay (PAMPA): similar to IAM, PAMPA can only measure passive diffusion but more accurately correlates to jejunal intestinal permeability of compounds. In this assay, the drug is diluted in a buffer (donor solution) and topped with an immiscible barrier of a lipid layer on a filter plate usually consisting of a phospholipid such as phophatidyl choline in dodecane or egg lecithin. On top of the layer added is a pH-adjusted buffer (acceptor solution). The system is allowed to incubate for a set period of time and samples are collected from the original drug solution, the donor, and the acceptor solution after incubation and the concentration of the drug are measured. The advantage of this system is that the lipid layer is consistent and the compound is not forced through it as is the case in IAM. The thickness of the lipid layer, the pH of the buffer solution, and the composition of the lipid layer all contribute to the permeability rate and need to be carefully adjusted.

for Marks JAMA 2024 we need to answer these questions: 1-Describe a strategy you

for Marks JAMA 2024 we need to answer these questions:
1-Describe a strategy you

for Marks JAMA 2024 we need to answer these questions:
1-Describe a strategy you have used or observed that was successful at leading a person to choose to vaccinate or a strategy that was unsuccessful. Why do you think it was effective/ineffective?
2-How can pharmacists best answer the article’s call to “provide accurate plain-language information regarding the individual and collective benefits and risks of vaccination” in their professional practice? What barriers exist?
3-The article authors note that “It is often difficult for a person to take action when the individual risk of an outcome is relatively low, even when the consequences of complications are high, and the population effects are substantial.” How can healthcare professionals best communicate the potential risks/harms of inaction (e.g. not taking a particular drug, not vaccinating), particularly when these harms may be experienced by persons other than the individual themselves?
AND for Arnozy CID 2024 we need to answer these questions:
1-Which part of the article did you find most impactful? Why?
2-How can the personal stories of healthcare professionals be used to positively impact public health?