The autoregulatory mechanism of glomerular filtration rate (GFR) involves two ke
The autoregulatory mechanism of glomerular filtration rate (GFR) involves two key processes:
Myogenic Mechanism:Afferent arterioles constrict in response to increased blood pressure, limiting blood flow into the glomeruli.
Afferent arterioles relax when blood pressure is low, allowing more blood into the glomeruli to maintain a stable GFR.
Tubuloglomerular Feedback (TGF) Mechanism:Macula densa cells in the nephron’s distal tubule monitor sodium chloride levels in the filtrate.
High sodium chloride levels trigger afferent arteriole constriction, reducing GFR.
Low sodium chloride levels prompt afferent arteriole dilation, increasing GFR.
These mechanisms ensure a constant GFR despite variations in blood pressure, maintaining effective kidney function