Respond to your colleagues on and respectfully agree or disagree with your colle

Respond to your colleagues on and respectfully agree or disagree with your colle

Respond to your colleagues on and respectfully agree or disagree with your colleague’s assessment and explain your reasoning. In your explanation, include why their explanations make physiological sense or why they do not. Include 2 scholars sources, cited within the reply: The 22-year-old male developed an allergic reaction to the allergy shots. Genetics plays a role in allergic reactions. Evidence shows that allergy and its related diseases have a high heritability rate. Genome-wide association studies (GWAS) have linked allergic reactions to chromosomes such as 17q21 and GSDMA genes. Genes such as ORMDL3 are highly heritable and stimulate eosinophil release and sphingolipid synthesis in allergic reactions (Kabesch & Tost, 2020). Other genes that play a role in allergic reactions include IL1RL1, which regulates the release of interleukins, PLCL1 for phospholipase, LLP for transcription factor, PTGER4 for prostaglandin, and SLC25A46 for cytokines. The patient developed symptoms, including difficulty swallowing, nausea, and feeling weak. The exposure to the allergy shots stimulated IgE. The activation led to an increase ininflammatory mediators such as interleukins, histamines, prostaglandins, and eosinophils (Alashkar Alhamwe et al., 2020). The inflammatory mediators cause bronchoconstriction and constriction of the smooth muscles, hence, the symptoms. The patient developed an allergic reaction because he had been sensitized before. The exposure to the allergen led to the activation of IgE. A subsequent exposure led to an anaphylactic reaction, as evidenced by symptoms such as difficulty swallowing and breathing. Several cells are involved in the allergic reaction. They include histamines, eosinophils, interleukins, prostaglandins, and cytokines (Kabesch & Tost, 2020). These cells stimulate inflammatory processes, which contribute to the development of the symptoms seen in the case study. ​Age is one of the factors that would change my response. Aging is associated with considerable physiological and functional changes. Elderly patients have reduced renal excretion, hepatic metabolism, and drug absorption. The risk of polypharmacy among elderly patients is also high due to multiple comorbidities (Li et al., 2021). Therefore, the client could have developed the symptoms due to drug interactions if he was elderly.